Genesis 13:1 NIV:
So Abram went up from Egypt to the Negev, with his wife and everything he had, and Lot went with him.
God had told Abram to get out of his father's house, with all he had, and set out for a place he would show him. God knew where he was taking Abram to and he had to get him out of his background and familiar sphere of influence. This is where our life's lessons begin: trusting God is not always convenient. God may have to take you out of familiar environments so he can bless you abundantly and in a way that it will be obvious that self had nothing to do with it.
Be careful, however, who you set out on the journey with. God called Abraham to himself; Abraham called Lot to himself. It is the One who calls that can sustain the journey and it is He who commissions an assignment that will provide the resources required. Lot's end is a classic reminder that even man's best intentions don't always end well for man. We cannot start and conclude God's assignment by our strength, neither can we take on additional responsibilities outside his guidance.
Let this be a lesson to us all: we were not sent to save the entire world. That's Jesus' assignment and he's doing it well. Ours is to key into that part he needs us to do and rely on his strength to finish well. Don't take with you anybody or anything that God had not approved. It will weigh you down. Don't forget: it is only the man who received the vision that will set out in directions that others do not understand. Every other person is just along for the ride. His time of favour is here.